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Allopurinol Side Effects On The Liver


Modern day medicine has advanced to a rate that most modern diseases have a mortal enemy in the form of a drug. Sadly, it advanced so fast that our understanding of its deadly side-effects is left too far behind.
Contrary to popular belief, even the most common medication we use can damage us. Many were deprived of their lives simply because medications are released even if its side effects are yet unknown and then withdrawn from the market.
Some drugs however, remain in circulation in the market despite their deadly side-effects because no other solution is accepted yet. These drug’s side-effects are as deadly as those who were withdrawn from the market. One good example of this is allopurinol side effects. Liver disease, severe skin diseases and hypersensitivity syndromes are some of its deadly effects. This article aims to explain the side effects of allopurinol affecting the liver
The Liver
The liver is a bustling industrial zone filled with both manufacturing and processing plants AND warehouses. It is responsible for filtering our blood by segregating the usable and waste product entering the liver. The usable products are segregated again by kind. For instance, the sugar is refined into glucose and is redistributed to the body for usage. Excess glucose and nutrients are temporarily stored in the liver for future use. Toxic and unusable products are sent away to the urinary tract to be excreted.
Allopurinol side effects: Liver
Now that you know the importance of the liver, you are now aware that the destruction of this organ is extremely life-threatening. Yes. Allopurinol can totally ruin your body by ruining your liver. In fact, all drugs can but allopurinol is especially good at doing it. It is poorly understood how but the shroud veiling the secretes of allopurinol is not thick enough to deny the side effects it can cause
Basically, allopurinol (just like any other meds) adds to the burden of the liver and kidney. But this is a minor effect. Allopurinol is a xanthine oxidase inhibitor. This means that it bonds with xanthine oxidase, the enzyme which bonds with purine. It competes with purine so purine will not be broken down into uric acid. Allopurinol is an attention seeker which reacts with purine xanthine oxidase so it will not react with purine. Now think of this; where does the purine not broken down go? It will return to the blood stream. Purine is important as a building block of the body so it is not considered as trash by the liver. The concentration of purine is not reduced, but the concentration of xanthine oxidase is reduced. Because purine is still present, the liver will continue to pump xanthine oxidase to break it down. The liver cannot produce tons of xanthine oxidase instantly, that is why allopurinol temporarily overpowers purine and lowers uric acid production. Put simply, allopurinol cheats your system and overburdens the liver. This is none but the beginning of allopurinol side effects. Liver damage will begin here. Further damage will begin as well, such as homeostatic disturbances in the regulation of the pH balance of the blood. Liver disease will also cause morbid diseases such as TEN.
Allopurinol can cause hepatotoxicity (poisoning of the liver) and eventually cause chronic or acute liver disease. This occurs through different ways.  
Granuloma
Foreign substances are isolated by macrophages who are responsible in elimination of foreign substances in the body. It is still unclear what substance in allopurinol causes this.
This case will cause inflammation in the liver and necrosis, a condition wherein your own cells devour your other cells because of mistaking them for an enemy.
Cholestasis
This is caused by physical blockage of the pathway of bile. This can cause indigestion and further imbalance throughout the body.
What can I do now?
Truly, everyone can be stricken by fear when it comes to allopurinol side effects. Liver destruction, homeostasis disruption and morbid diseases are only few of its side effects. Surely, if you have depended on allopurinol all your life, you are asking now “what else can I do? Is there a substitute for allopurinol?”
Fortunately, there is a NATURAL substitute for allopurinol. There is still hope to cure your disease.
This can be done by reversing the root cause of hyperurecimia, gout or whatever disease giving you a reason to take allopurinol. This root is called acidosis.
Now that you learned important subjects such as allopurinol side effects, liver functions and many others, if is time for you to find out how to reverse your acidosis, the root of many modern diseases.



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