Modern day medicine
has advanced to a rate that most modern diseases have a mortal enemy in the
form of a drug. Sadly, it advanced so fast that our understanding of its deadly
side-effects is left too far behind.
Contrary to popular belief,
even the most common medication we use can damage us. Many were deprived of
their lives simply because medications are released even if its side effects
are yet unknown and then withdrawn from the market.
Some drugs however,
remain in circulation in the market despite their deadly side-effects because
no other solution is accepted yet. These drug’s side-effects are as deadly as
those who were withdrawn from the market. One good example of this is
allopurinol side effects. Liver disease, severe skin diseases and
hypersensitivity syndromes are some of its deadly effects. This article aims to
explain the side effects of allopurinol affecting the liver
The Liver
The liver is a
bustling industrial zone filled with both manufacturing and processing plants AND
warehouses. It is responsible for filtering our blood by segregating the usable
and waste product entering the liver. The usable products are segregated again
by kind. For instance, the sugar is refined into glucose and is redistributed
to the body for usage. Excess glucose and nutrients are temporarily stored in
the liver for future use. Toxic and unusable products are sent away to the
urinary tract to be excreted.
Allopurinol side effects: Liver
Now that you know the
importance of the liver, you are now aware that the destruction of this organ
is extremely life-threatening. Yes. Allopurinol can totally ruin your body by
ruining your liver. In fact, all drugs can but allopurinol is especially good
at doing it. It is poorly understood how but the shroud veiling the secretes of
allopurinol is not thick enough to deny the side effects it can cause
Basically, allopurinol
(just like any other meds) adds to the burden of the liver and kidney. But this
is a minor effect. Allopurinol is a xanthine oxidase inhibitor. This means that
it bonds with xanthine oxidase, the enzyme which bonds with purine. It competes
with purine so purine will not be broken down into uric acid. Allopurinol is an attention seeker which
reacts with purine xanthine oxidase so it will not react with purine. Now
think of this; where does the purine not broken down go? It will return to the blood stream. Purine is important as a
building block of the body so it is not considered as trash by the liver. The concentration of purine is not reduced,
but the concentration of xanthine oxidase is reduced. Because purine is
still present, the liver will continue to pump xanthine oxidase to break it
down. The liver cannot produce tons of xanthine oxidase instantly, that is why
allopurinol temporarily overpowers purine and lowers uric acid production. Put
simply, allopurinol cheats your system and overburdens the liver. This is none
but the beginning of allopurinol side effects. Liver damage will begin here.
Further damage will begin as well, such as homeostatic disturbances in the
regulation of the pH balance of the blood. Liver disease will also cause morbid
diseases such as TEN.
Allopurinol can cause
hepatotoxicity (poisoning of the liver) and eventually cause chronic or acute
liver disease. This occurs through different ways.
Granuloma
Foreign substances are
isolated by macrophages who are responsible in elimination of foreign
substances in the body. It is still unclear what substance in allopurinol causes
this.
This case will cause
inflammation in the liver and necrosis, a condition wherein your own cells
devour your other cells because of mistaking them for an enemy.
Cholestasis
This is caused by
physical blockage of the pathway of bile. This can cause indigestion and
further imbalance throughout the body.
What can I do now?
Truly, everyone can be
stricken by fear when it comes to allopurinol side effects. Liver destruction,
homeostasis disruption and morbid diseases are only few of its side effects.
Surely, if you have depended on allopurinol all your life, you are asking now
“what else can I do? Is there a substitute for allopurinol?”
Fortunately, there is
a NATURAL substitute for allopurinol. There
is still hope to cure your disease.
This can be done by
reversing the root cause of hyperurecimia, gout or whatever disease giving you
a reason to take allopurinol. This root is called acidosis.
Now that you learned
important subjects such as allopurinol side effects, liver functions and many
others, if is time for you to find out how to reverse your acidosis, the root
of many modern diseases.
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