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Zyloric for GOUT fills me with DOUBT


When it comes to alternative medicine, practitioners are usually met with raised eyebrows and a handful of questions of credibility. But, there are times that it is the classical medicine that deserves doubt.
Once a person hears of a seemingly magical elixir, he/she is immediately teeming with questions and usually with thoughts like “What a quack!”, but never did they know that their trusted medicine is a quack as well.
This article aims to answer the question “What is the use of zyloric?”
Zyloric for GOUT fills me with DOUBT
Sometimes, when you ask a gout sufferer “Hey, what is the use of Zyloric?”, they end up saying “Zyloric lowers uric acid! It cures my gout.” To them, Zyloric is their salvation from the agony of pain and inflammation. Unfortunately, it is not this way. In fact, there are times that it is the other way around.
First of all, Zyloric DOES NOT flush uric acid out, just like any other brands of allopurinol out there. It does not even help in the process. What it does is it pause the production of uric acid for a while. This gives you more time to flush the existing uric acid. Unfortunately, the next batch of uric acid will be more than before.
Take a look at this abstracted example:
 If 10 units of uric acid exists in the body and you can only flush 10 units out a day, adding more will make uric acid accumulate. Say, you produced 11 units one day. There will be an excess 1 unit! Ten days and there will be an excess of ten units. If paused, the body will not produce any unit for a day, hence the body will be given time to flush the excess 10 units. Unfortunately, it will produce 20 units the next day! Uric acid production is only paused, NOT stopped, remember? If the body can flush 10 units out, there will still be an excess of 10 units!  20-10=10! Did the uric acid you have magically vanish? NOPE.
So, if you will ask me “What is the use of Zyloric?” I will say that “If it does anything, that is to pause the production of uric acid”.
How Zyloric PAUSES The Production of Uric Acid
Zyloric is a brand name for allopurinol, which then falls under a category called Xanthine Oxidase Inhibitors.
Xanthine Oxidase inhibitors have the same mechanism of action: to disrupt the body’s natural process of purine metabolism.
Purine is a macromolecule that is utilized by the body to manufacture the nucleotides of the DNA. Hence, it is present everywhere in you. Added to this is the fact that every food you eat contains purine! Take note that purine is a macromolecule so it will not be filtered out by the kidneys. This means that excess purine has to be broken down to be excreted.
Purine will be broken down into uric acid to be excreted. When the liver detects excess purine in the bloodstream, it mobilizes its own private army of an enzyme called Xanthine Oxidase which is responsible for breaking purine down into uric acid. This enzyme will be disrupted by Zyloric. Zyloric is a purine analog which means that is has a structure almost similar to purine in structure. Xanthine Oxidase will mistake Zyloric for purine. Hence, they become too occupied with Zyloric. No purine is broken down! Unfortunately, the liver will keep on bombarding purine with xanthine oxidase as long as it detects excess purine. This means that once no more Zyloric exists to disrupt XO, all the purine you disrupted will be converted into uric acid. In a rush! Ironically, this can cause severe gout attacks. Good job allopurinol!
Therefore, we can conclude that the answer to the question “What is the use of Zyloric” is:
To pause the production of uric acid only to double the trouble later. Zyloric does nothing! It is in the negative side of the scale because it does more harm and disruption than good. Taking nothing is much better than taking Zyloric. After all, zero has a higher value than negative ten!

 Read next: Is Gouty Tophi Removal Possible? 


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