Skip to main content

Zyloric for GOUT fills me with DOUBT


When it comes to alternative medicine, practitioners are usually met with raised eyebrows and a handful of questions of credibility. But, there are times that it is the classical medicine that deserves doubt.
Once a person hears of a seemingly magical elixir, he/she is immediately teeming with questions and usually with thoughts like “What a quack!”, but never did they know that their trusted medicine is a quack as well.
This article aims to answer the question “What is the use of zyloric?”
Zyloric for GOUT fills me with DOUBT
Sometimes, when you ask a gout sufferer “Hey, what is the use of Zyloric?”, they end up saying “Zyloric lowers uric acid! It cures my gout.” To them, Zyloric is their salvation from the agony of pain and inflammation. Unfortunately, it is not this way. In fact, there are times that it is the other way around.
First of all, Zyloric DOES NOT flush uric acid out, just like any other brands of allopurinol out there. It does not even help in the process. What it does is it pause the production of uric acid for a while. This gives you more time to flush the existing uric acid. Unfortunately, the next batch of uric acid will be more than before.
Take a look at this abstracted example:
 If 10 units of uric acid exists in the body and you can only flush 10 units out a day, adding more will make uric acid accumulate. Say, you produced 11 units one day. There will be an excess 1 unit! Ten days and there will be an excess of ten units. If paused, the body will not produce any unit for a day, hence the body will be given time to flush the excess 10 units. Unfortunately, it will produce 20 units the next day! Uric acid production is only paused, NOT stopped, remember? If the body can flush 10 units out, there will still be an excess of 10 units!  20-10=10! Did the uric acid you have magically vanish? NOPE.
So, if you will ask me “What is the use of Zyloric?” I will say that “If it does anything, that is to pause the production of uric acid”.
How Zyloric PAUSES The Production of Uric Acid
Zyloric is a brand name for allopurinol, which then falls under a category called Xanthine Oxidase Inhibitors.
Xanthine Oxidase inhibitors have the same mechanism of action: to disrupt the body’s natural process of purine metabolism.
Purine is a macromolecule that is utilized by the body to manufacture the nucleotides of the DNA. Hence, it is present everywhere in you. Added to this is the fact that every food you eat contains purine! Take note that purine is a macromolecule so it will not be filtered out by the kidneys. This means that excess purine has to be broken down to be excreted.
Purine will be broken down into uric acid to be excreted. When the liver detects excess purine in the bloodstream, it mobilizes its own private army of an enzyme called Xanthine Oxidase which is responsible for breaking purine down into uric acid. This enzyme will be disrupted by Zyloric. Zyloric is a purine analog which means that is has a structure almost similar to purine in structure. Xanthine Oxidase will mistake Zyloric for purine. Hence, they become too occupied with Zyloric. No purine is broken down! Unfortunately, the liver will keep on bombarding purine with xanthine oxidase as long as it detects excess purine. This means that once no more Zyloric exists to disrupt XO, all the purine you disrupted will be converted into uric acid. In a rush! Ironically, this can cause severe gout attacks. Good job allopurinol!
Therefore, we can conclude that the answer to the question “What is the use of Zyloric” is:
To pause the production of uric acid only to double the trouble later. Zyloric does nothing! It is in the negative side of the scale because it does more harm and disruption than good. Taking nothing is much better than taking Zyloric. After all, zero has a higher value than negative ten!

 Read next: Is Gouty Tophi Removal Possible? 


Labels:

Comments

Post a Comment

Popular posts from this blog

Can I Take Colchicine and Ibuprofen Together?

Do you believe that we have survival instincts? Surely, this is one of the controversial psychological and physiological topic that garnered controversy. Nowadays, it is almost explainable by a solid scientific proof. Pain and stress are two of the aspects of our fight-and-flight mechanism that can force us to do something about what is causing them. At times, they come as a powerful combination when pain is the root cause of stress. However, there can be these unfortunate times that no matter how much we desire to remove the pain, we can do nothing. One such instance is during gout attacks. Surely enough, the pain indicates that something is not supposed to be in there, but we are left helpless. We can’t just cut our limbs off to remove the pain. Hence, the idea of taking multiple medications to ease the pain was born (even if those medications were not prescribed at all). This article aims to answer the question “can I take colchicine and ibuprofen together?” ...
Post a Comment
Read more

Allopurinol Side Effects On The Liver

Modern day medicine has advanced to a rate that most modern diseases have a mortal enemy in the form of a drug. Sadly, it advanced so fast that our understanding of its deadly side-effects is left too far behind. Contrary to popular belief, even the most common medication we use can damage us. Many were deprived of their lives simply because medications are released even if its side effects are yet unknown and then withdrawn from the market. Some drugs however, remain in circulation in the market despite their deadly side-effects because no other solution is accepted yet. These drug’s side-effects are as deadly as those who were withdrawn from the market. One good example of this is allopurinol side effects. Liver disease, severe skin diseases and hypersensitivity syndromes are some of its deadly effects. This article aims to explain the side effects of allopurinol affecting the liver The Liver The liver is a bustling industrial zone filled with both manufact...
Post a Comment
Read more

How Temperature Affects The Formation of Gouty Tophi?

Have you ever wondered why gouty tophy only found on certain parts of the body such as earlobe, fingers, elbow, knee, and almost only on the surface of the skin. Before I explain about this phenomena, I have to briefly discuss about the heat regulation of human body. Every cell in the body does generate energy and some heat in the process of metabolism, but for a healthy human body, majority of the body heat is generated in organs that are constantly working such as heart, liver, and brain, thus the center of heat is in the torso and and middle of the head. But there must be some channels for the body to dissipate excess heat in order to maintain the body temperature at 37.5 degree Celsius.  The 3 Channels of Body Heat Dissipation Heat Distribution Put a hand close to your mouth or nose and then slow breathe out, you can feel the warm air blowing on you hand, that is heat dispersion through breathing. If you dare, try to collect your pee in a paper cup and then dip...
2 comments
Read more