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Gout Pain Relief Options - Paracetamol or Ibuprofen?


The list for medications to cure the gouty inflammation and pain is long and exhaustive. Worse, people have different recommendations leaving sufferers with misinformation. Along this misinformation comes confusion and along this confusion comes the deprivation of the privilege of an effective remedy. This site aims to remove such confusion, and this article aims to cure a specific bewilderment. Which is better for gout? Paracetamol or ibuprofen?
The Similarities between Paracetamol and Ibuprofen
The only similarity between these two medications is the fact that both of them have side effects and that they both relieve pain. ONLY PAIN. The similarity ends here.
The DIFFERENCE Between Paracetamol and Ibuprofen
Ibuprofen can treat the pain and inflammation though it requires a larger dosage to treat the inflammation. On the other hand, paracetamol can treat the pain but not the inflammation. It can, but it will require a dosage that can lead to overdose.
Both medications have their own share of side effects. Ibuprofen, just like other NSAIDs, can inflict ulcer, cardiovascular diseases and a variety of allergic reactions while paracetamol can cause liver damage and asthma.
If you will observe, paracetamol is less effective than ibuprofen but has less side effects. However, overdose or long-term dependence on paracetamol can be very devastating because of the way it is metabolized. One of the ways in which paracetamol is metabolized results to NAPQ1, a poison that can cause liver damage or poisoning. On the other hand, metabolism of ibuprofen is toxic to the kidneys.
To tap it all, paracetamol causes liver toxicity while ibuprofen causes kidney toxicity. Ibuprofen is more effective, but it has worse side effects especially to the stomach.  
Ibuprofen Mechanism of Actions – Why can treat inflammation and paracetamol can not?
The answer lies on the mechanisms of how we feel pain.
Throughout our body, nociceptors are scattered. These are your body’s alarm system that signals impending danger. This signal is what we call PAIN. For you to feel pain, the body adjusts the sensitivity of the nociceptors. Ibuprofen messes with this adjustment.
For the pain-sensitivity to be adjusted, dying cells (from the wound or from a foreign invasion such as the uric acid crystal in gout) releases arachidonic acid. When this acid comes in contact with cyclooxygenase, they are converted into prostaglandins which is responsible for adjusting the sensitivity of the nociceptors. Ibuprofen disrupts those cyclooxygenase enzymes so that they can not convert the arachidonic acid into prostaglandins.
Ibuprofen can disrupt cyclooxygenase throughout the body. On the other hand, paracetamol can only affect the cyclooxygenase in the central nervous system. Hence, it is more effective in relieving headache than treating pain and inflammation.
There are two types of cyclooxygenase; cox1 and cox2. Aside from converting arachidonic acid into prostaglandins, cox1 is responsible for maintaining the mucus lining of the stomach as well. Since the stomach is the landing zone of medications, its cox1 will be the first ones to suffer as ibuprofen begins its invasion. This is the reason why ibuprofen and other NSAIDS can ruin the stomach.
Conclusion
Both medications won’t cure gout. They are only temporary pain relief. Both of them carry their own side effects. It is up to you to choose. The one that is not effective but has no side effects, or the one that is effective but has severe side effects? Or maybe the one that has a HEALING CRISIS but will ELIMINATE GOUT ONCE AND FOR ALL!?
Calkaline
Uric acid is not the only problem you should deal with. In the first place, uric acid will not accumulate without help especially because your body is very good at disposing its own trash. A person with a normal kidney and liver can flush all those uric acic out.
The question now is, what helps uric acid accumulate?
                  Acidosis
Acidosis is the state of having too much acids in the body. With too much acids, the attention of the kidneys and the liver will be divided between flushing uric acid and other acids. This means that the rate at which uric acid is being flushed out will be reduced. This means that uric acid will accumulate faster! Hence, you should eliminate acidosis if you want to eliminate gout.
Calkaline can do the job, but it is an article in its own right. Go ahead, read the article about how Calkaline eliminates acidosis and cure your gout!

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