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Long Term Side Effects of Zyloric - Dependency


Medications, even though they are not guaranteed to work, are guaranteed to have some degree of side effects. In fact, there are times that the side effect has a better chance of setting in than the relieving effect!
The same is true for gout medications. Instead of having a lower uric acid level and a joint not suffering from the torture of gouty pain, it is the exact opposite that can happen!
This article aims to explain Zyloric side effects. Long term (and even short term!) consumption of this medicine can lead to various conditions.
Zyloric Dependence
Zyloric creates an illusion that you are indeed dependent. It makes you believe that it truly lowers uric acid. Strangely, a person who stopped taking Zyloric have way above average level of uric acid. Is this because of Hyperuricemia? I don’t think so. Take note that this does not mean that Zyloric is a drug that simply depends on the power of suggestion for efficacy. Zyloric has indeed a mechanism to lower uric acid, but there is more into it than that.
This is the first in the list of Zyloric side effects: long term dependence!
Once you take Zyloric, uric acid level from lab tests seem to lower. Yes, it did but only for a while. Try to spot taking Zyloric for a couple of days, have a lab test and be astounded as you see that your uric acid level has peaked again despite the fact that you have been maintaining a low-purine diet. This is because Zyloric neither flush uric acid out nor stop its production. Zyloric only DELAYS the production of uric acid. Hence, the amount of uric acid not produced today will be produced next time, along with the next batch of uric acid.
Zyloric does this by inhibiting the breakdown of purine. Zyloric is a xanthine oxidase inhibitor, which means that it will pretend to be purine so that the enzyme xanthine oxidase (which is an enzyme responsible for breaking purine down into uric acid) will bond with it. This means that there will be little XO left to react with actual purine. Hence, little xanthine oxidase will be left to bind with purine. This means that little uric acid will be left! However, try to recall the fact that Zyloric only delays uric acid production. This is because purine will never be excreted unless you convert it to uric acid! It is a macromolecule that has to be broken down to be granted clearance by the kidney.
Once you stop taking Zyloric, all those undisposed purine will be bombarded with Xanthine Oxidase. Say hello to high uric acid! Say hello to severe gout attack, the third side effect of Zyloric! Long-term dependence on Zyloric is equivalent to long-term suffering from severe gout attacks.
Some claim that the reason why severe gout attacks follow as you take Zyloric (and any other brand of Allopurinol) is because of the sudden uric acid drop. This is true in a limited scope. The true reason is when the concentration of Zyloric in your body drops, xanthine oxidase begins to break purine down in an INCREDIBLY FAST rate. The liver will pump more and more xanthine oxidase as it detects excess purine, and there will always be too much excess if you have been taking Zyloric. Indeed, this acid will be a fine addition to the uric acid crystal in the joint.
The good news is, Zyloric will less likely damage the kidneys (unless the uric acid rush decides to give you a uric acid kidney stone). However, liver damage is a known Zyloprim Side Effect. Long-term exposure of the liver to Zyloprim will toast it! Worse, the liver keeps on being overburdened by pumping Xanthine Oxidase to no avail.
Lastly (and the worst), Zyloprim can cause Toxic Epidermal Necrolysis and Steven-Johnson Syndrome, two fatal skin diseases that will peel you alive! This is the most vicious Zyloprim side effect. Long-term or short-term, Zyloprim can cause either of these two diseases. Death is terrifying. But to die because your skin peeled-off or your organs are eaten by your own cells? UNSPEAKABLE. Makes me wonder. Is it really worth taking Zyloric?
Read Next: Can I Get Gout In The Fingers? Yes! You will!

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